Physiol Rev 2008, 88:125–172.PubMedCrossRef 15. Liao R, Sun TW, Yi Y, Wu H, Li YW, Wang JX, Zhou J, Shi YH, Cheng YF, Qiu SJ: Expression of TREM-1 in hepatic stellate cells and prognostic value in hepatitis Batimastat cost B-related hepatocellular carcinoma. Cancer Sci 2012, 103:984–992.PubMedCrossRef 16. Ju MJ, Qiu SJ, Fan J, Xiao YS, Gao Q, Zhou J, Li YW, Tang ZY: Peritumoral activated hepatic stellate cells predict poor clinical outcome in hepatocellular carcinoma after curative selleck chemicals llc resection. Am J Clin Pathol 2009, 131:498–510.PubMedCrossRef 17. Coulouarn C, Corlu A, Glaise

D, Guenon I, Thorgeirsson SS, Clement B: Hepatocyte-stellate cell cross-talk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma. Cancer Res 2012, 72:2533–2542.PubMedCrossRef 18. Sancho-Bru KPT-8602 in vitro P, Bataller R, Gasull X, Colmenero J, Khurdayan V, Gual A, Nicolas JM, Arroyo V, Gines P: Genomic and functional characterization of stellate cells isolated from human cirrhotic livers. J Hepatol 2005, 43:272–282.PubMedCrossRef 19. Jiang F, Parsons CJ, Stefanovic B: Gene expression

profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol 2006, 45:401–409.PubMedCrossRef 20. De Minicis S, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner DA, Schwabe RF: Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology 2007, 132:1937–1946.PubMedCrossRef 21. Xia Y, Chen R, Song Z, Ye S, Sun R, Xue Q, Zhang Z: Gene expression profiles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum. J Cancer Res Clin Oncol 2010, 136:309–321.PubMedCrossRef

22. Liao R, Sun J, Wu H, Yi Y, Wang JX, He HW, Cai XY, Zhou J, Cheng YF, Fan J: High expression of IL-17 and IL-17RE associate with poor prognosis of hepatocellular carcinoma. J Exp Clin Cancer Res 2013, 32:3.PubMedCrossRef 23. Lemmers A, Moreno C, Gustot T, Marechal R, Degre D, Demetter P, de Nadai P, Geerts A, Quertinmont E, Vercruysse V: The interleukin-17 pathway is involved in human alcoholic liver disease. Hepatology 2009, 49:646–657.PubMedCrossRef 24. Li Y, Tian B, Yang J, Zhao L, Wu X, Ye SL, Liu YK, Tang ZY: Stepwise metastatic human before hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics. J Cancer Res Clin Oncol 2004, 130:460–468.PubMedCrossRef 25. Whittaker S, Marais R, Zhu AX: The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 2010, 29:4989–5005.PubMedCrossRef 26. Van Rossen E, Vander Borght S, Van Grunsven LA, Reynaert H, Bruggeman V, Blomhoff R, Roskams T, Geerts A: Vinculin and cellular retinol-binding protein-1 are markers for quiescent and activated hepatic stellate cells in formalin-fixed paraffin embedded human liver. Histochem Cell Biol 2009, 131:313–325.