AZD9291 noncognitive disorders in AD have been diffusely investigated, and a large number of descriptions have become available in the past decade. However, most reports on the behavioral disturbances in FTD have not specifically focused on this type of dementia; they are, in fact, comparative studies between AD and FTD. In addition, since the scales for assessing the behavioral deficit were originally devised for AD,

it is likely that disorders more specific to FTD were not sufficiently identified until diagnostic tools were devised explicitly for FTD. For many reasons, studies of behavioral disturbances Inhibitors,research,lifescience,medical in dementia are often difficult to compare. First of all, reports largely reflect the tool adopted for assessing the syndrome. In addition, Inhibitors,research,lifescience,medical groups in which studies have been conducted may be heterogeneous, either for disease severity and clinical expression, or the selection criteria adopted to group the patients. Misdiagnoses seriously hinder achieving a reliable description and a quantification of the behavioral manifestation. The use of standard diagnostic criteria

for patient selection does not Inhibitors,research,lifescience,medical in fact guarantee a correct diagnosis,21,22 and autopsy confirmation should be obtained. However, only in a minority of reports is the diagnosis supported by pathology. For example, Inhibitors,research,lifescience,medical inclusion of patients with dementia with Lewy bodies (DLB) in AD groups is likely to produce an overestimation of the frequency of hallucinations in this form of dementia. Finally, studies not corroborated by pathological data are necessarily tautological to some extent. For example, since the presence of behavioral disorders constitutes a diagnostic Inhibitors,research,lifescience,medical criterion for FTD,3 only FTD patients with behavioral disorders are selected for inclusion, and this could artificially increase their true frequency. At the same time, symptoms not specifically mentioned in the diagnostic criteria adopted are

misidentified, and their occurrence is thus underestimated. The assessment of behavioral disturbances L-NAME HCl also suffers from other limitations compared with the assessment of cognitive disorders. Symptom detection and quantification are not based on direct observation of patients and mostly rely on caregivers’ reports, and the influence caregivers’ variables may have on symptom description and quantification is not always adequately taken into account. Noncognitive disorders in AD and FTD: a brief review AD Many behavioral disorders have been reported in AD patients, ranging from mood changes to psychoses and to modification in social conduct.18,23,24 There may be several explanations for this heterogeneity First, the disease itself is heterogeneous in its noncognitive manifestations. Occasionally, noncognitive disorders may characterize the onset.