ACE genotypes were distributed as follows: DD was present in 16 (50%), ID in 12 (37.5%) and II in four (12.5%) PCOS patients, and DD in seven (22.6%), ID in 20 (64.5%)

and II in four (12.9%) of healthy subjects. The frequency of D and I alleles were found in 69% and 31% of the PCOS group and 55% and 45% in the control group, respectively. There were no significant differences regarding the genotypic distribution and allelic frequency between the groups. However the ACE DD genotype was significantly associated with serum insulin concentrations and HOMA-IR measurement (both P = 0.005). ACE DD genotype is associated with an increased insulin resistance in women with PCOS. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“This study screened FOXO3 coding regions find more for mutations in a sample of 114 Chinese women with premature ovarian failure and discovered six novel single-nucleotide

FAK inhibitor variants: c.71C>A (p.Pro24His), c.140C>T (p.Pro47Leu), c.184G>A (p.Asp62Asn), c.1652C>T (p.Ser551Phe), c.1697C>G (p.Gly566Ala) and c.1185G>A (silent). The nonsynonymous single-nucleotide variants, c.71C>A (p.Pro24His), c.140C>T (p.Pro47Leu), c.184G>A (p.Asp62Asn), c.1652C>T (p.Ser551Phe) and c.1697C>G (p.Gly566Ala), were not detected in any of 100 controls. These missense mutations might cause abnormal oocyte apoptosis and primordial follicle activation, thereby adversely affecting early follicle depletion in the ovary. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“Serum human chorionic gonadotrophin (HCG) concentration is nearly always used to predict pregnancy but there is little data on the clinical utility of the ratio of HCG(21)/HCG(14) combined with double measurement of serum HCG. A total of 1762 cycles were retrospectively analysed for serum HCG concentration and ratio of HCG(21)/HCG(14) on days 14 and 21 after embryo transfer to determine whether the ratio combined with concentration is the optimal predictor of pregnancy. The medians of HCG concentration on days 14 and 21 combined with the ratio of HCG(21)/HCG(14) see more were

calculated for non-viable, viable and heterotopic pregnancies. HCG concentrations of 290 IU/l on day 14 and 2970 IU/l on day 21 were regarded as the cut-off values to predict viable pregnancy, and values of 630 and 12,000 IU/l, respectively, were regarded as the cut-off values to predict multiple pregnancy. The ratio of HCG(21)/HCG(14) in the viable pregnancy group was significantly higher than that in the non-viable pregnancy group (15.86 versus 5.27, P < 0.0001). For heterotopic pregnancy, the ratio of HCG(21)/HCG(14) was 11.93. It was concluded that HCG concentration on days 14 and 21 combined with the ratio of HCG(21)/HCG(14) provides a useful predictor of pregnancy outcome. A ratio >15 may predict viable pregnancy.