(C) 2011 Elsevier Ireland Ltd. All rights reserved.”
“Allometry has been extensively used in the modern day drug development scenario to predict the human relevant parameters LY2835219 order (clearance, Cl, and volume
of distribution at steady state, V(ss)) from animal data. The applicability of allometry in the prediction of human parameters for irinotecan (CAS 97682-44-5), an important topoisomerase I inhibitor, has been retrospectively investigated. Literature pharmacokinetic data has been gathered for both irinotecan and its main metabolite, SN-38 (CAS 86639-52-3), from several animal species. The corresponding human parameters were predicted using allometry (Cl and Vss for irinotecan; Cl/F for SN-38). Although irinotecan has a complex metabolism and disposition profile,
it appeared that simple allometry predicted satisfactorily the human values for Cl (1.7648W(0.669)) and Vss (3.1277W(0.9044)) for irinotecan. On the contrary, Cl/F for SN-38 was over predicted by simple allometry (53.389W(1.2273)); and the applicability of bile correction factor rendered Cl/F of SN-38 to be closer GSK2126458 clinical trial to the observed human value (8.964W(1.3108)). The investigation suggests that prospective allometric approaches may aid in the development of future compounds in this important pharmacological and chemical class of cytotoxics.”
“This review article covers the concepts and the theory behind using nanoparticles (NPs) in separation
science. Recent examples show the use of NPs in capillary electrophoresis and electrochromatography. Specific examples involve the use of NPs in liquid, gas and ion chromatography, along with recent applications showing the use of NPs in microchip electrophoresis. Future trends and conclusions are also covered. (C) 2013 Elsevier Ltd. All rights reserved.”
“Objective: To evaluate the incidence of perioperative bleeding among children with mild bleeding disorders who underwent adenotonsillar surgery in our hospital and were treated with our perioperative bleeding prophylaxis protocol.
Methods: Retrospective chart review was aimed at determining the perioperative bleeding rate in children with mild bleeding MAPK inhibitor disorders subjected to our prophylactic protocol while undergoing adenotonsillar procedures. Low von Willebrand factor (LVWF), unspecific platelet function disorders (UPFD) and mild factor VII deficiency were considered as mild bleeding disorders. The protocol utilizes intravenous desmopressin, tranexamic acid, NSAID avoidance, and overnight observation.
Results: Between 2004 and 2009, 44 children with mild bleeding disorders underwent adenotonsillar procedures in our hospital and were treated with the protocol. One patient (LVWF + UPFD) developed perioperative bleeding (2.3%).