“
“Purpose: To investigate the association between magnetic resonance (MR) imaging-depicted intraplaque hemorrhage (IPH) in the carotid artery wall and the risk of eFT-508 mw future ipsilateral cerebrovascular events in men with asymptomatic moderate carotid stenosis by using a rapid three-dimensional T1-weighted fat-suppressed spoiled gradient-echo sequence.

Materials and Methods: The institutional ethics review board approved this retrospective chart review and waived the requirement for written informed consent. All patients gave informed verbal consent at follow-up telephone interviews.

Ninety-one men (mean age, 74.8 years; range, 47-88 years) who attended a vascular clinic between 2003 and 2006, who had asymptomatic carotid stenosis (50%-70% at Doppler ultrasonography), and who had undergone MR imaging for IPH detection were retrospectively identified. Seventy-five men with 98 eligible carotid arteries were included in the study. Patients were followed for a minimum of 1 year (mean follow-up, 24.92 months; range, 12-43 months). Kaplan-Meier

survival and univariate Cox regression analyses were conducted to compare future ipsilateral cerebrovascular event rates between carotid arteries with and those without MR-depicted IPH.

Results: Of the 98 carotid arteries included, 36 (36.7%) had MR-depicted IPH. Six cerebrovascular events (two strokes and four transient ischemic attacks) occurred in the carotid arteries with IPH, as compared with no clinical events in the carotid arteries

without IPH. Univariate Cox regression analysis confirmed that MR-depicted IPH was associated with an increased risk of cerebrovascular events (hazard ratio, 3.59; 95% GKT137831 clinical trial confidence interval: 2.48, 4.71; P < .001). MR-depicted IPH negatively predicted outcomes (negative predictive value = 100%).

Conclusion: In this cohort with asymptomatic moderate carotid stenosis, MR-depicted IPH was associated with future ipsilateral cerebrovascular events. Conversely, patients without MR-depicted IPH remained PCI-34051 research buy asymptomatic during follow-up. The absence of IPH at MR imaging, therefore, may be a reassuring marker of plaque stability and of a lower risk of thromboembolism. (C) RSNA, 2009″
“The cellular effects of nobiletin on human pancreatic cancer cells (PANC-1) and the mechanisms by which nobiletin inhibits the proliferation of these cells were investigated. A MTT assay and flow cytometry were used to examine cell proliferation and apoptosis, respectively. A Western blot assay was used to examine expression levels of the apoptotic proteins bax, bcl-2, and p53. NOB induced apoptosis in these cells via up-regulation of the proapoptotic protein bax and down-regulation of the antiapoptotic proteins bcl-2 and p53. The normal cell cycle of PANC-1 cells was arrested by NOB with a significant increase in the proportion of G0/G1 phase cells (p < 0.05) and a significant decrease in the proportion of S phase cells (p < 0.05).