For every window in this set, for each seed in a network, a correlation map is computed.
Correspondingly a Z-score is computed to generate both the final RSN connectivity maps and the cross-network interaction. In both cases, the Z-score is obtained by contrasting the correlation value of each voxel with the average correlation in the whole brain with both quantities averaged across all the MCW windows obtained in all sessions (see Figure S1, step D). Therefore, to compute the final RSN connectivity maps the Z-score maps were statistically thresholded at p < 0.05 (FDR) as in Figures 1B and 1C and transformed to binary maps. Finally, the binary maps, one for each seed, were multiplied (“AND logic” operation) to obtain the topography displayed in Figure 1. Thus, only voxels that show consistent correlation across all seed sets are retained. These steps are reported in Figure S1 Paclitaxel (step E). The cross network IWR 1 interaction matrices reported in Figures 2 and 3 instead are obtained by simply reporting for each node the obtained Z-score values in the network to which the node belongs. Therefore, the computed matrices presented in are not symmetrical: rows define the interaction between one network/node ( Figures 2 and 3) with other networks/nodes during the first network’s MCWs. The columns define the correlation between a first network/node with a second network/nodes during the second networks’ MCWs.
This step is reported in Figure S1 (step F). A detailed description of the EMCW algorithm and in particular the computation f Z-scores can be found in the Supplemental Information. This work was supported by the European Community’s Seventh
Framework Programme (FP7/2007-2013), Grant Agreement HEALTH-F2-2008-200728 “BrainSynch” NIH grant, and NIH grants 1R01MH096482 to M.C., and the Human Connectome Project (1U54MH091657-01) from the 16 National Institutes of Health Institutes and Centers that support the NIH Blueprint for Neuroscience Research. “
“Psychostimulant drugs of abuse very rapidly increase extracellular levels of dopamine in the brain; however, repeated exposure to these drugs over long periods of time is necessary to produce the persistent alterations in behavior that can lead to drug addiction (Hyman et al., 2006). This temporal distinction between the pharmacological Rolziracetam and the behavioral actions of psychostimulants has long suggested that molecular mechanisms downstream of dopamine receptor activation, which include the induction of new gene transcription, are critical for mediating behavioral adaptations induced by these drugs. In the two decades since it was discovered that transcription of the immediate-early gene Fos is rapidly induced in striatal neurons after cocaine or amphetamine administration ( Graybiel et al., 1990), a wealth of molecular genetic studies have defined the functional contributions of key transcriptional regulatory pathways to psychostimulant-induced behaviors ( Robison and Nestler, 2011).