05), were at or above their baseline level of self-reported IADL function at 10years. The reasoning and

speed-of-processing interventions maintained their effects on their targeted cognitive abilities at 10years (reasoning: effect size=0.23, 99% CI=0.09-0.38; speed of processing: effect size=0.66, 99% CI=0.43-0.88). Memory training effects were no longer maintained for memory performance. Booster training produced additional and durable improvement for SRT2104 ic50 the reasoning intervention for reasoning performance (effect size=0.21, 99% CI=0.01-0.41) and the speed-of-processing intervention for speed-of-processing performance (effect size = 0.62, 99% CI=0.31-0.93).\n\nConclusionEach Advanced Cognitive Training for Independent and Vital Elderly cognitive intervention EGFR inhibitor resulted in less decline in self-reported IADL compared with the control group. Reasoning and speed, but not memory, training resulted

in improved targeted cognitive abilities for 10 years.”
“Aims: We report our initial 3-year experience of chemoradiotherapy for cervical cancer with computed tomography-based image-guided high dose rate (HDR) brachytherapy using the tandem-ring applicator.\n\nMaterials and methods: Twenty-eight patients were treated between February 2005 and December 2007. All patients received initial external beam radiotherapy (EBRT) followed by HDR brachytherapy (planned dose 21 Gy to point A in three fractions over 8 days). For each insertion, a computed tomography scan was obtained with the brachytherapy applicator in situ. The cervix, uterus and organs at risk (OAR) were contoured FK228 inhibitor on the computed tomography images to create an individualised dosimetry plan. The D(90) (the dose delivered to 90% of the tumour target), V(100) (the percentage of tumour target volume receiving 100% of the prescribed dose) and the minimum dose in the most exposed 2 cm(3) volume (D(2cc))

of rectum, bladder and bowel were recorded. The equivalent dose in 2 Gy fractions delivered by EBRT and brachytherapy was calculated.\n\nResults: The 3-year cancer-specific survival was 81%, with a pelvic control rate of 96%. In 24 patients, a D90 74 Gy(alpha/beta 10) was achieved. The only patient with local recurrence had a D(90) of 63.8 Gy(alpha/alpha 10). The overall actuarial risk of serious late morbidity was 14%. Seventeen patients had satisfactory OAR doses using the standard loading pattern. Seven patients had modifications to reduce the risk of toxicity, whereas two had modifications to improve the tumour dose. Comparison with a previous cohort of patients treated with chemoradiotherapy and a conventionally planned low dose rate triple source brachytherapy technique showed an improvement in local pelvic control of 20% (P = 0.04).