Conclusions. Relevant interactions among the emotional face-processing stages exist in the non-clinical range of social anxiety
that may ultimately attenuate amygdala responses. Future research will help to establish the role of this effect in a clinical context.”
“Background. Functional brain abnormalities have been repeatedly demonstrated in schizophrenia but there is little data concerning their progression. For such studies to have credibility it is first important to establish the reproducibility of functional imaging techniques. The current study aimed to examine these factors in healthy controls and in unmedicated subjects at high genetic risk of the disorder: (i) Selleck Sonidegib to examine the reproducibility of task-related activation patterns, (ii) to determine if there were any progressive functional changes in high-risk subjects versus controls reflecting inheritance of the schizophrenic trait, and (iii) to examine changes over time in relation to fluctuating positive psychotic symptoms (i.e. state effects).
Method. Subjects were scanned performing the Hayling sentence completion test
on two occasions 18 months apart. Changes in activation were examined in controls and high-risk subjects (n=16, n=63). Reproducibility check details was assessed for controls and high-risk subjects who remained asymptomatic at both time points (n=16, n=32).
Results. Intra-class correlation values indicated good agreement Aldehyde_oxidase between scanning sessions. No significant differences over time were seen between the high-risk and control group; however, comparison
of high-risk subjects who developed symptoms versus those who remained asymptomatic revealed activation increases in the left middle temporal gyrus (p = 0.026).
Conclusions. The current results suggest that functional changes over time occur in the lateral temporal cortex as high genetic risk subjects become symptomatic, further, they indicate the usefulness of functional imaging tools for investigating progressive changes associated with state and trait effects in schizophrenia.”
“Background. Depression is a frequent mood disorder that affects around 33% of stroke patients and has been associated with both poorer outcome and increased mortality. Our aim was to test the possible association between inflammatory and neurotrophic Molecular markers and the development of post-stroke depression.
Method. We Studied 134 patients with a first episode of ischemic stroke without previous history of depression or speech disorders. We screened for the existence of major depression symptoms in accordance with DSM-TV criteria and a Yesavage Geriatric Depression Scale (GDS) score > 11 at discharge and 1 month after stroke.