Free Radic Biol Med 2013, 64:20–30.PubMedCentralPubMed 12. Gee HE, Ivan C, Calin GA, Ivan M: HypoxamiRs and Cancer: From Biology to Targeted Therapy. Antioxid Redox Signal 2013. 13. Chan SY, Loscalzo J: MicroRNA-210: a unique and pleiotropic hypoxamir. Cell Cycle 2010,9(6):1072–1083.PubMedCentralPubMed 14. Devlin

C, Greco S, Martelli F, Ivan M: miR-210: More than a silent player in hypoxia. IUBMB life 2011,63(2):94–100.PubMed 15. Ivan M, Huang X: OSI-027 solubility dmso miR-210: Fine-Tuning the Hypoxic Response. Adv Exp Med Biol 2014, 772:205–227.PubMed 16. Camps C, Buffa FM, Colella S, Moore J, Sotiriou C, Sheldon H, Harris AL, Gleadle JM, Torin 2 Ragoussis J: hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer. Clin Cancer Res 2008,14(5):1340–1348.PubMed 17. Gee HE, Camps Pifithrin-�� C, Buffa FM, Patiar S, Winter SC, Betts G, Homer J, Corbridge R, Cox G, West CM, Ragoussis J, Harris AL: hsa-mir-210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer. Cancer 2010,116(9):2148–2158.PubMed 18. Giannakakis A, Sandaltzopoulos R, Greshock J, Liang S, Huang J, Hasegawa K, Li C, O’Brien-Jenkins A, Katsaros D, Weber BL, Simon C, Coukos G, Zhang L: miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer. Cancer Biol Ther 2008,7(2):255–264.PubMedCentralPubMed 19. Huang

X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, Giaccia AJ: Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell 2009,35(6):856–867.PubMedCentralPubMed 20. Kelly TJ, Souza AL, Clish CB, Puigserver P: A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. Mol Cell Biol 2011,31(13):2696–2706.PubMedCentralPubMed 21. Nakada C, Tsukamoto Y, Matsuura K, Nguyen TL, Hijiya N, Uchida T, Sato F, Mimata H, Seto M, Moriyama M: Overexpression of miR-210, a downstream target of HIF1alpha, causes centrosome amplification in renal carcinoma cells. J Pathol 2011,224(2):280–288.PubMed 22. Zhang 3-mercaptopyruvate sulfurtransferase Z, Sun H, Dai H, Walsh RM, Imakura M, Schelter J, Burchard

J, Dai X, Chang AN, Diaz RL, Marszalek JR, Bartz SR, Carleton M, Cleary MA, Linsley PS, Grandori C: MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT. Cell Cycle 2009,8(17):2756–2768.PubMed 23. McCormick RI, Blick C, Ragoussis J, Schoedel J, Mole DR, Young AC, Selby PJ, Banks RE, Harris AL: miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis. Br J Cancer 2013,108(5):1133–1142.PubMedCentralPubMed 24. Mutharasan RK, Nagpal V, Ichikawa Y, Ardehali H: microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects. Am J Physiol Heart Circ Physiol 2011,301(4):H1519–1530.PubMedCentralPubMed 25.