From this study, 3 MTHFR single nucleotide polymorphisms showing association with migraine in the Norfolk Island population have been identified, thus reinforcing the potential role of MTHFR in migraine susceptibility. Further studies will continue to build a gene profile of variants involved in the complex disease migraine and improve understanding of the underlying genetic causes of this disorder. “
“(Headache

2012;52:822-824) “
“(Headache 2010;50:143-145) We report the case of a woman with short-lasting unilateral, neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) whose severe headache attacks ceased after percutaneous balloon compression of the Gasserian ganglion. The patient remains pain free after 10-year follow-up. Hedgehog antagonist This may be the first literature report of SUNCT in

Chile. “
“(Headache buy AZD3965 2010;••:••-••) We report a case of a patient with status migrainosus unresponsive to analgesic therapy in whom electroencephalographic recording revealed an epileptic origin. Intravenous administration of lorazepam induced the prompt resolution of the symptoms. “
“The clinical and radiographic manifestations of spontaneous intracranial hypotension are highly variable and many patients do not satisfy the 2004 International Classification of Headache Disorders criteria. We developed new diagnostic criteria for spontaneous intracranial hypotension based on cases we have seen reflecting the variable manifestations of the disorder. These criteria provide a basis for change when the classification criteria are next revised. The diagnostic criteria consist of A, orthostatic headache; B, the presence of at least one of the following: low opening pressure (≤60 mm H2O), sustained improvement of symptoms medchemexpress after epidural blood patching, demonstration

of an active spinal cerebrospinal fluid leak, cranial magnetic resonance imaging changes of intracranial hypotension (eg, brain sagging or pachymeningeal enhancement); C, no recent history of dural puncture; and D, not attributable to another disorder. “
“In March of 2014, the Food and Drug Administration (FDA) approved the first medical device to be used for the prevention of migraine. This device is a 2 AAA battery-powered electrical stimulator applied to the forehead using a headband-like device manufactured by the Cefaly Technology Company of Herstal, Belgium intended for individuals with episodic migraine with or without aura, who have 2–8 attacks per month. A self-adhesive electrode pad is positioned over the center of the forehead, and the portable device is held in place with a plastic headband that rests on top of the ears (see Fig. 1). The device activates a low level electrical current intended to stimulate the upper branches of the trigeminal nerve which transmits some of the pain associated with migraines.