Pharmaceutical companies do not play any financial role in the CTV decision making process even though representatives may be invited to make specific presentations at the C59 wnt price discretion of the

committee. Once a year, the CTV holds a specific meeting during which industry representatives are formally invited to present their activities; this allows the CTV to remain up-to-date about advances in the private sector. Special interest or lobbying groups do not provide any funding or other resources, nor do they intervene in the decision making process. Two contrasting examples of decision making by the committee illustrate the gap between the committee’s recommendations and the ultimate decisions that were put into place. The first example concerns HPV vaccination.

The Ministry of Health and the media exerted pressure on the CTV by publicly announcing that there would be reimbursement of the HPV vaccine before the CTV issued its opinion. The difficulty in assessing the vaccine’s cost-benefit status and target populations prompted the CTV to seek an economic evaluation and to decline on issuing its full recommendations by selleck kinase inhibitor the requested date (rather, it issued limited recommendations concerning screening by cervical smear). Its final opinion was issued a few months later. However, media coverage of the HPV vaccine was very strong, and some people even considered it excessive. This subsequently led to vaccinations being overwhelmingly administered

to the “catch-up” bracket group (women aged 15–23 years), with very little allocated to cover vaccinations for the targeted cohort group (girls under 14 years of age). The other example concerns the meningococcus C vaccine, in which this case, there was no external pressure exerted on the CTV. The CTV reconsidered previous recommendations that were made on vaccination campaigns conducted in hyper-endemic areas. The epidemiological findings from the areas covered by the Cell press vaccination campaigns, which were compared with national data, played an important role in the decision making process. An economic evaluation resulted in the development of a vaccination strategy that is based on a single-dose immunization of one-year-old children, accompanied by a large “catch-up” effort for children, adolescents, and young adults. This was recommended in order to promote herd immunity, which can protect infants not targeted by vaccination. In France, more than 80% of the vaccines are administered by mainly general practitioners (GPs), as well as private practitioners and pediatricians. Thus, a major issue lies in how to disseminate the recommendations and have them understood and accepted by physicians. The CTV uses various tools for sharing information on CTV activities with the medical profession and the public.