revisional MGB were 89 +/- 12.8 min vs. 144 +/- 15 min (p < 0.01) and l.85 +/- 0.8 day vs. 2.35 +/- 1.89 day (p < 0.01). No deaths occurred within 30 days of surgery. Short-term complications occurred in 2.7% for primary vs. 11.6% for revisionnal MGB (p < 0.01). Five (0.5%) patients presented with leakage from the gastic tube but none had anastomotic leakage. Four (0.4%) patients, all with revisionnal MGB, presented with severe bile reflux and were cured by www.selleckchem.com/products/jph203.html stapling the afferent loop and by a latero-lateral jejunojejunostomy. Excessive weight loss
occurred in four patients; two were reversed and two were converted to sleeve gastrectomy. Maximal percent excess weight loss (EWL) of 72.5% occurred at 18 months. Weight regain subsequently occurred with a mean variation of -3.9% EWL at 60 months. The 50% EWL was achieved for 95% of patients at 18 months and for 89.8% at 60 months. MGB is an effective, relatively low-risk, and low-failure bariatric procedure. In addition, it can be easily revised, converted, or reversed.”
“Objectives: The aim of this study is to investigate whether glutamine (GLN) enhances heat shock protein-25 (Hsp-25) and heat shock CA3 purchase protein-72 (Hsp-72) expressions and attenuates cerebral ischaemic injury in rat cardiac arrest model.
Methods: Rats survived from cardiac arrest model were randomly assigned to CPR + GLN group (0.75 g/kg of alanyl-glutamine, n = 6) or CPR
group (same volume of 0.9% saline, n = 6). Additional 6 rats were used for SHAM group. For the outcome measures, neurologic deficit score (NDS, 0-80) was checked at 24 h and 72 h after cardiac arrest. At 72 h after cardiac arrest, rats were euthanised and the brain was harvested. Then, right hemisphere was used for cresyl-violet and TUNEL staining. Left hemisphere was used for Western blot analysis of phosphorylated heat shock factor-1 (p-HSF-1), Hsp-25,
Hsp-72, and cleaved caspase-3. Kruskal-Wallis test and Mann-Whitney U post hoc test with Bonferroni correction were used for the analysis.
Results: Resuscitation variables were not different between CPR and CPR + GLN. NDS in CPR + GLN was higher than that in CPR (p < 0.017) and lower than that in SHAM (p < 0.017) at both 24 h and 72 h. p-HSF-1, Hsp-25 and Hsp-72 expressions in CPR + GLN were significantly enhanced (p < 0.017) than GSK690693 cell line those in other groups. Cleaved caspase-3 expression in CPR was significantly higher (p < 0.017) than in SHAM and CPR + GLN. Ischaemic and TUNEL-positive neurons were more frequently observed in CPR than in CPR + GLN.
Conclusions: Glutamine attenuates cerebral ischaemic injury in cardiac arrest model of rats and this is associated with the enhancement of Hsp-25 and Hsp-72 expressions. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“Background and objective: More than 100 000 Japanese die of pneumonia every year. The number of people residing in nursing homes is increasing with the ageing of the population.