Study design Retrospective study. Sample population Twenty-five horses with corneolimbal SCC. Procedures Medical records of horses undergoing AG-014699 mouse surgical
tumor resection followed by either topical MMC therapy (0.04%) or CO2 laser ablation between the years of 2004 and 2010 were reviewed. Recurrence and complications were compared between groups and within MMC subgroups defined by the time at which treatment was initiated relative to surgery. Results Therapy with topical MMC resulted in a nonrecurrence rate comparable to that achieved with CO2 laser ablation (82.4% vs. 85.7%, respectively). Initiation of MMC following epithelialization of the surgical site a mean of 15 days postoperatively did not result in increased recurrence rates relative to treatment
in the immediate postoperative period. Vision- or globe-threatening complications tended to occur with greater frequency in horses receiving topical MMC in the immediate postoperative period (5 of 6 major complications) relative selleck chemicals to following epithelialization of the surgical site (1 of 6 major complications). Conclusions Horses receiving adjunctive topical MMC therapy were no more likely to experience tumor recurrence than were horses undergoing CO2 laser ablation in the horses in this study. Initiation of two to three rounds of MMC following epithelialization of the surgical site results in fewer major complications and achieves comparable disease resolution relative to treatment in the immediate postoperative period.”
“Background and aims So far, there have been no reports assessing double tract (DT) reconstruction see more after distal gastrectomy for gastric cancer, which maintains the duodenal passage
of food. The aim of this study was to evaluate the clinical results of DT reconstruction compared with Roux-en-Y (RY) and Billroth I (BI) reconstruction following distal gastrectomy.
Patients and methods Outcomes following DT (33 patients), RY (38 patients), or BI (47 patients) reconstructions were investigated retrospectively. These outcomes included postoperative esophagogastroscopic findings, the angle of His measured from postoperative esophagogastrography, and the quality of life, determined by the Gastrointestinal Symptom Rating Scale (GSRS) 1 year after surgery.
Results The degree and extent of gastritis was significantly lower in patients who had undergone DT or RY compared with BI reconstruction (P < 0.05). The angle of His was significantly greater in patients who had undergone BI rather than RY or DT reconstruction (P < 0.05) and was significantly greater in patients with reflux esophagitis (P < 0.05). Using the GSRS, patients who underwent DT or RY reconstructions had significantly lower reflux and indigestion than patients who had undergone BI reconstruction. The length of the lesser curvature of the remnant stomach did not differ significantly between the three reconstruction procedures.