Women undergoing infertility treatment with low SR-B1 expression in granulosa cells were noted to have plasma estradiol levels half the normal levels and a significantly lower number of retrieved oocytes. In vitro, deficiency of SR-B1 is associated with lower progesterone secretion in human granulosa cells. Certain SR-B1 polymorphisms have been associated with lower follicular progesterone levels and a significantly lower clinical pregnancy rate.
Summary
Deficiency of SR-B1, particularly due to single-nucleotide polymorphisms, could explain some features of female human infertility.”
“A
non-puerperal uterine inversion in advanced uterovaginal prolapse is a rare occurrence. Even more unusual is the presence of bladder calculi in these two conditions, which has not been documented before. We report AC220 a case of acute urinary retention secondary to severe uterovaginal
prolapse associated with uterine inversion and multiple bladder calculi.”
“Purpose: To employ response surface methodology (RSM) for statistical optimization of formulation factors in the preparation of celecoxib-loaded microspheres.
Methods: Celecoxib microspheres were prepared by solvent evaporation method. Biodegradable/biocompatible polymers, Eudragit L-100 and polyvinyl pyrrolidone, were used in the encapsulation procedure. A central composite design employing Stat-Ease design Expert (R), version 7.0.3 having a unit value of alpha was used according to reference protocols to assess the influence of two independent variables this website URMC-099 datasheet (i.e., the concentration of the two polymers used) on four dependent variables (i.e., recovery, encapsulation efficiency
and % drug released). The polymers used were Eudragit-L100 (X-1) and polyvinyl pyrrolidone (X-2). The microspheres were characterized for size, shape, recovery (%), entrapment efficiency and drug release.
Results: The recovered total weight of microspheres ranged between 49.4 +/- 3.1 and 91.1 +/- 4.8 %, and it decreased with increase in the concentration of PVP. Entrapment efficiency was in the range of 54.1 +/- 2.9 to 95.6 +/- 3.7 %, and was also dependent on polymer concentration. The release of celecoxib increased with decrease in Eudragit L-100 concentration and increase in PVP concentration. Higuchi model was the best-fit drug release from all the formulations. Korsemeyer-Peppas release exponent (n) indicates that drug release pattern was non-Fickian diffusion.
Conclusion: Using RSM, it is possible to optimize the drug release properties of celecoxib-loaded microspheres. A celecoxib-loaded microsphere formulation with optimum recovery, entrapment efficiency and release behavior was proposed.”
“The ethyl acetate phase of Limoniastrum guyonianum Boiss. was used to separate 10 fractions by centrifugal partition chromatography. Phenolic contents and biological capacities were evaluated in all fractions.