RESULTS: There were 213 patients with no anemia, 230 with mild anemia and 209 with marked anemia. Patients with marked anemia (compared to mild or no anemia) were older in years (54.9 +/− 9.8 vs 53.7 +/− 10.2 vs 52.7 +/− 10.2: p=0.032), more likely to be male (71.3% vs 68.2% vs 56.3%:p=0.003), had a lower GFR at LT (67.8 +/− 36.7 vs 78.0 +/− 40.0 vs 84.5 +/− 42.6: p<0.001) and were more likely to have pre-LT diabetes (31.7% vs 21.8% vs 15.5%: p<0.001). There were marked differences in patient survival and development of renal insufficiency
over time using Kaplan-Meier PD0325901 molecular weight analysis. Patients with marked anemia had 5 year survival of 73.7% compared to 83.7% in the mild anemia group and 91.4% in the no anemia group (p<0.001). Differences in severe RI were even more pronounced. Patients with marked anemia had rates of severe RI at 3 and 5 years of 28.7% and 35.1% compared to 10.4% and 13.2% for mild anemia and 8.8% and 11.4% for no anemia (p<0.001). In multivariate analysis, marked anemia three months after LT was significantly associated with both death and severe RI. Compared to no anemia, the presence of marked anemia was associated with severe RI with
a hazard ratio (HR) of 2.39 (CI 1.46-3.91: Ku-0059436 nmr p<0.001). In multivariate analysis, other variables associated with severe RI were GFR at LT (HR 1.01 per ml/ min: p<0.001) female sex (HR 2.47: p<0.001) and diabetes before LT (HR 1.97: p=0.003). Marked anemia (vs no anemia) was associated with patient death with a HR of 2.16 (CI 1.283.63: p=0.004). CONCLUSIONS: The presence of marked anemia three months after
LT is common and is an early, significant and independent predictor of poor patient outcomes after LT including death and the development of severe renal insufficiency. The use of this variable along with other proven 上海皓元 variables, should help identity patients for aggressive renal sparing measures. Disclosures: Dilip Moonka – Advisory Committees or Review Panels: Gilead; Grant/Research Support: Bristol-Myers Squibb, Genentech; Speaking and Teaching: Merck, Genentech, Gilead The following people have nothing to disclose: Wadih Chacra, Mohammad Elbatta, Aishwarya Kuchipudi, Alexander Weick, Charlotte Burmeister, George Divine Introduction: Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, is a ‘tolerance-sparing’ immunosuppressant used in solid organ transplantation. mTOR regulates diverse functions of professional antigen-presenting cells, in particular dendritic cells (DCs), and has important roles in the activation of conventional T cells and the function and proliferation of regulatory T cells (Treg). Aim: currently, no data are available concerning the impact of everolimus on DC and Treg in stable liver transplant patients. Therefore, the aim of this pilot study was to analyze peripheral blood DC subsets and Treg in 10 liver transplant patients exposed to everolimus (mTOR).