Nanoparticles were characterized using microscopy and spectroscop

Nanoparticles were characterized using microscopy and spectroscopy techniques such as HRTEM, UV-Vis absorption spectroscopy and FTIR spectroscopy. X-ray diffraction analysis showed that the nanoparticles had face centered Taselisib nmr cubic structure with crystalline nature. FTIR spectroscopy showed

the presence of different functional groups, such as hydroxyl and carbonyl, involved in the synthesis of nanoparticles. The antifungal activity of fluconazole and itraconazole was enhanced against the tested pathogenic fungi in the presence of Ag-NP and confirmed from increase in fold area of inhibition. This environmentally friendly method of biological synthesis can be easily integrated for various medical applications.”
“Methyl 1-aryl-3-aroyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates reacted with 3-methyl-4-phenyl-1H-pyrazol-5-amine to give methyl 7-arylcarbamoyl-6-aroyl-2-methyl-3-phenylpyrazolo[1,5-a]-pyrimidine-5-carboxylates. The

molecular and crystalline structures of methyl 6-benzoyl-7-(4-chlorophenylcarbamoyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylate were studied by X-ray analysis.”
“This report describes a previously healthy adolescent male who developed a nasal septal abscess following trauma and subsequent multifocal arthritis with Group A Streptococcus requiring surgery and prolonged antibiotics. This sequence of events has not been previously described in the literature. This report highlights the importance of early recognition and treatment of traumatic

nasal septal BAY 63-2521 hematoma to reduce the risk of suppurative complications. (C) 2010 Elsevier Ireland Ltd. All rights reserved.”
“Micro-aeration, which refers to the addition of very small amounts of air, is a simple technology that can potentially be incorporated in septic tanks to improve the digestion performance. The purpose of this study was to investigate and buy 8-Bromo-cAMP compare the effects of micro-aeration on anaerobic digestion of primary sludge under septic tank conditions. 1.6 L batch reactor experiments were carried out in duplicate using raw primary sludge, with 4.1 % total solids, and diluted primary sludge, with 2.1 % total solids. Reactors were operated for 5 weeks at room temperature to simulate septic tank conditions. Micro-aeration rate of 0.00156 vvm effectively solubilised chemical oxygen demand (COD) and improved the subsequent degradation of COD. Micro-aeration also increased the generation of ammonia and soluble proteins, but did not improve the reduction in total and volatile solids, or the reduction in carbohydrates. Experiments using diluted sludge samples showed similar trends as the experiments with raw sludge, which suggest that initial solids concentration did not have a significant effect on the degradation of primary sludge under septic tank conditions.”
“BACKGROUND: Non-high-density lipoprotein (HDL) cholesterol is recommended as a secondary lipid goal treated initially with lifestyle modification.

Sensibility performance was assessed quantitatively (% respondent

Sensibility performance was assessed quantitatively (% respondent endorsement) and qualitatively via written feedback.

Results: The WLQ-25 was considered most comprehensive (endorsed by 92.8%), the WALS performed best in terms of understandability (97.6%) and suitability of response options (97.9%), and the RA-WIS was favored in terms of length (91.6%). Consistent sensibility performance between OA and RA was found. The WALS (32.6%) and WLQ-25 (30.0%) were moderately preferred in the

final overall appraisal.

Conclusion: Sensibility criteria were generally met by all five at-work productivity measures. Variable endorsement levels across specific sensibility attributes were also revealed across Birinapant datasheet the measures compared. (C) 2013 Elsevier Inc. All rights reserved.”
“Root organs of Hemidesmus indicus are traditionally known for multipurpose medicinal applications. Root extracts of H. indicus contained 2-hydroxy-4-methoxybenzaldehyde (MBALD) as principal fragrant phenolic compound. This methoxybenzaldehyde was shown to have inhibitory potential

click here against diphenolase activity of the tyrosinase. The present work explored the effects of this MBALD (both in crude extracts and pure forms) on the monophenolase activity. The lag time of reaction and the activity of monophenolase were affected upon supplementation of methoxybenzaldehyde. The increase in lag time indicated an inhibition of monophenolase activity

which subsequently led to the reduction in total tyrosinase activity. MBALD was shown to be more potent than vanillin in inhibiting monophenolase activity. Inhibition kinetic analysis confirmed the same observation, with a higher K-m value (0.395 mM) was determined for monophenolase reaction in presence of MBALD as compared to K-m value of tyrosinase without any inhibition. As compared to pure MBALD, the crude root extract of H. indicus showed greater inhibition against monophenolase activity, which was also evidenced from the extension in lag time. This indicates its potential application in herbal products. (C) 2013 Elsevier B.V. All rights reserved.”
“Background Verubecestat cell line Abdominal wall component release (AWCR) is an operation that frequently restores the abdominal wall integrity in both sick and anatomically complex patients. The patients reported herein are different from the widely reported but somewhat less complex trauma patient, such as following damage control laparotomy. AWCR has acceptable postoperative outcomes in terms of infection, hernia, and fistula rates.

Methods We describe the application of AWCR in 63 consecutive patients, in whom only 11 (17%) had complementary prosthesis use. Unlike many previous reports of AWCR in trauma patients, 47 (75%) of these patients had permanent stomas. These patients had undergone a total of 103 prior abdominal operations (mean 1.

211 +/- 0 153 for the placebo, 3-mg OTO-104, and 12-mg OTO-104 gr

211 +/- 0.153 for the placebo, 3-mg OTO-104, and 12-mg OTO-104 groups, respectively; corresponding to 42%, 56% and 73% reductions in vertigo frequency, respectively. Similar results were observed for tinnitus, measured by the Tinnitus Handicap Inventory (THI-25).

Conclusion: OTO-104 was safe and well tolerated. Although the sample size was small, the data suggest 12 mg of OTO-104 was associated with a clinically meaningful reduction in vertigo frequency compared to placebo 3 months after treatment.”
“Background: The overall analysis of the rivaroxaban versus warfarin in Japanese patients with

atrial fibrillation (J-ROCKET AF) trial revealed that rivaroxaban was not inferior to warfarin with respect to the primary safety outcome. In addition, there was a strong trend for a reduction in the rate of stroke/systemic embolism with rivaroxaban compared

with warfarin. MK0683 Methods: In this subanalysis of the J-ROCKET AF trial, we investigated the consistency of safety and efficacy profile of rivaroxaban versus warfarin among the subgroups of patients with previous stroke, transient ischemic attack, or non-central nervous system systemic embolism (secondary prevention group) and those without (primary prevention group). Results: Patients in the secondary prevention group were 63.6% of the overall population of J-ROCKET AF. In the secondary prevention group, the rate of the principal safety outcome (% per year) was 17.02 in rivaroxaban-treated this website patients and 18.26 in warfarintreated patients (hazard ratio [HR] 0.95; 95% confidence interval [CI] 0.70-1.29), while the rate of the primary efficacy endpoint was 1.66 in rivaroxaban-treated patients and 3.25 in warfarin-treated patients (HR 0.51; 95% CI 0.23-1.14). There were no significant

interactions in the principal safety and the primary efficacy endpoints of rivaroxaban compared to warfarin between the primary and secondary prevention groups (P = .090 and .776 for both interactions, respectively). Conclusions: The safety and efficacy profile of rivaroxaban compared with warfarin was consistent among patients in the primary prevention group and those in the secondary prevention group.”
“OBJECTIVE: We evaluated the incidence of and the main risk factors associated with cutaneous adverse events in patients with chronic inflammatory arthritis following anti-TNF-alpha therapy.

METHODS: Vorasidenib A total of 257 patients with active arthritis who were taking TNF-a blockers, including 158 patients with rheumatoid arthritis, 87 with ankylosing spondylitis and 12 with psoriatic arthritis, were enrolled in a 5year prospective analysis. Patients with overlapping or other rheumatic diseases were excluded. Anthropometric, socioeconomic, demographic and clinical data were evaluated, including the Disease Activity Score-28, Bath Ankylosing Spondylitis Disease Activity Index and Psoriasis Area Severity Index. Skin conditions were evaluated by two dermatology experts, and in doubtful cases, skin lesion biopsies were performed.

HPLC analysis showed that onion peel extracts contained well-know

HPLC analysis showed that onion peel extracts contained well-known antioxidant compounds, including epicatechin and morin. All of the flavonoids measured and oxygen radical absorbance capacity (ORAC) values were greatest in the methanolic extract. ORAC was strongly correlated with total phenolic content (r(2)=0.980). The total radical trapping antioxidant potential was greatest in the ethanolic extract. DPPH radical-scavenging activity was in the order of acetonic>ethanolic>methanolic

extract. In contrast, the reducing capacity of intracellular oxidative stress was almost the same in all extracts. In addition, pretreatment with onion peel significantly reduced human leukocyte DNA damage induced by H2O2 or 4-hydroxynonenal. Taken together, the results indicate that onion peel has antioxidative and antigenotoxic properties.”
“Tunable second harmonic generation of pulsed CO(2) laser radiation in a GaSe Apoptosis inhibitor crystal was demonstrated. The nonlinear optical properties of

GaSe and phase-matching conditions were investigated, and the best fitted dispersion relationships for this crystal were also determined. External conversion efficiency of 0.1% with unfocused pumped radiation had been achieved and maximum single pulse energy of 0.19 mJ was generated at 5.3 mu m. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3415533]“
“Poly(ethylene terephthalate) (PET) sheets of different crystallinity were obtained by annealing the amorphous PET (aPET)

sheets at 110 degrees C for various times. The peaks of enthalpy recovery and double cold-crystallization in the annealed aPET samples with different crystallinity were investigated by a temperature-modulated differential scanning calorimeter (TMDSC) and a dynamic mechanical analyzer (DMA). The enthalpy recovery peak around the glass transition temperature was pronounced in TMDSC nonreversing heat flow curves and was found to shift to higher temperatures with higher degrees of crystallinity. The magnitudes of the enthalpy recovery peaks were found to increase with annealing times for samples annealed <= 30 min but to decrease with annealing times for samples annealed >= 40 min. The nonreversing VE 822 curves also found that the samples annealed short times (<= 40 min) having low crystallinity exhibited double cold-crystallization peaks (or a major peak with a shoulder) in the region of 108-130 degrees C. For samples annealed long times (>= 50 min), the cold-crystallization peaks were reduced to one small peak or disappeared because of high crystallinity in these samples. The double cold-crystallization exotherms in samples of low crystallinity could be attributed to the superposition of the melting of crystals, formed by the annealing pretreatments, and the cold-crystallizations occurring during TMDSC heating. The ongoing crystallization after the cold crystallization was clearly seen in the TMDSC nonreversing heat flow curves.

A model based on nearest neighbor interaction of magnetically cou

A model based on nearest neighbor interaction of magnetically coupled elements is shown to predict the propagation of noise waves and the excitation of resonances in regular arrays. The power spectral density (PSD) of the noise is calculated for rectangular arrays of different dimension. It is shown that the effect of coupling is to alter the PSD, leaving the noise bandwidth unaltered. The implications for passive and active devices are examined using the simple model of a lossy one-dimensional interconnect

with distributed parametric amplification, and it is shown that the improvements to the noise factor offered by amplification are limited. (C) 2011 American Institute of Physics. [doi:10.1063/1.3600071]“
“We present two facile AZD1208 ic50 procedures to control catalytic activity of viral-templated palladium (Pd) nanocatalysts Specifically tunable and selective surface assembly of genetically modified Tobacco Mosaic Virus (TMV1cys) templates is exploited to control the loading of Pd nanocatalysts on solid substrates via preferential electroless deposition In the first

method the surface density of Pd-TMV complexes is controlled by varying the concentration of TMV solution for surface assembly Apparent surface density of Pd-TMV complexes from AFM images correlated well with the Pd loading observed via XPS and the catalytic activity in dichromate reduction an important environmental remediation reaction for detoxification of abundant inorganic wastes In the second method the Pd catalyst MEK inhibitor review loading is

controlled by varying the gold surface area on patterned silicon chips The catalytic activity of these chips correlated well with the surface area further indicating control over the location of active Pd catalysts via selective surface assembly of viral templates We envision that our approach to control the TMV surface density and specific location of catalysts by exploiting biologically derived template materials can be extended to other biotemplates and/or reaction systems via a wide range of tunable surface patterning/assembly techniques (C) 2010 Elsevier check details B V All rights reserved”
“Most members of the subfamily Mimosoideae have pantropical distributions, variable habits, and a basic chromosome number x = 13. We examined karyotypic evolution of 27 species of this subfamily occurring principally in northeastern Brazil by examining chromosomes stained with Giemsa. All of the species had semi-reticulated interphase nuclei and early condensing segments in the proximal region of both chromosome arms. The basic number x = 13 was the most frequent, with 2n = 2x = 26 in 19 of the species, followed by 2n = 4x = 52 and 2n = 6x = 78. However, the three species of the genus Calliandra had the basic number x = 8, with 2n = 2x = 16, while Mimosa cordistipula had 2n = 4x = 32.

Tau proteins form the major structural component of the neurofibr

Tau proteins form the major structural component of the neurofibrillary protein aggregates that correlate with cognitive decline in Alzheimer’s disease, and appropriately this abnormal tau is targeted for corrective action by the heat shock proteins that recognize sequence motifs that are normally masked though microtubule binding. This specific heat shock response to the formation of abnormal tau can also be targeted pharmacologically to inhibit the refolding pathways and drive the degradation of tau species that are thought to be pathogenic. This review discusses the recent advances of the

roles of heat shock proteins in this process.”
“Patients with Mendelian

susceptibility to mycobacterial diseases (MSMD) Selleck Evofosfamide mainly suffer from Mycobacterium and Salmonella infections, which are due to mutations in genes controlling Torin 2 ic50 the interleukin (IL)-12/ IL-23-dependent IFN-gamma production. We performed a molecular diagnosis in two Mexican patients with persistent mycobacterial infections. Patients 1 (P1) and 2 (P2) from two unrelated, non-consanguineous families from two villages near Mexico City developed bacille Calmette-Guerin (BCG) disease secondary to vaccination; patients and their families were studied at the immunological level for production and response to IFN-gamma. The beta 1 subunit of the IL-12 receptor (encoded by the IL12RB1 gene) was not expressed in cells from P1 or P2, or in two siblings of P1. Sequencing of the IL12RB1 gene showed the same point mutation 1791+2 T>G, homozygous in patients and heterozygous in parents. P1 and P2 died at the ages of 4 and 16 years, respectively, with disseminated and uncontrolled BCG disease and with Candida albicans infections in spite of multiple anti-mycobacterial drug treatments. One of P2′s siblings

also EPZ015938 manufacturer died following disseminated mycobacterial infection secondary to BCG vaccination. These are the first cases in Mexico of patients with BCG disease traced to a mutation in the IL12RB1 gene, with a fatal outcome. Doctors must be alert to the adverse reactions to BCG vaccination and to persistent Mycobacterium infections, and in such cases should investigate possible mutations in the genes of the IL-12/IL-23-IFN-gamma axis. (C) 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.”
“PURPOSE: To evaluate the correlation between changes in the susceptibility of bacteria and mutations in the quinolone-resistance determining region (QRDR) after 3 weeks of continuous fluoroquinolone instillation.

SETTING: Miyata Eye Hospital, Miyazaki, Japan.

METHODS: In this Prospective randomized study, gatifloxacin 0.3% eyedrops or levofloxacin 0.

5-nm-thick conducting layer, probably TinO2n-1 (n=2, 3, )

5-nm-thick conducting layer, probably TinO2n-1 (n=2, 3, …) buy DZNeP Magneli phase, and rutile TiO2, was performed. The results clearly showed that both

the rutile TiO2 and the thin interfacial layer contribute to carrier transport: the rutile TiO2 bulk region (mobility mu similar to 0.03 cm(2) V-1 s(-1)) and the 1.5-nm-thick interfacial layer (mu similar to 0.3 cm(2) V-1 s(-1)). The effective thickness of the interfacial layer, which was obtained from the S-n relation, was below similar to 3 nm, which agrees well with that of the TEM observation (similar to 1.5 nm), clearly showing that electric field modulation measurement of S-n relation can effectively clarify the carrier transport properties of a bilayer laminate structure. (C) 2011 American

17DMAG datasheet Institute of Physics. [doi: 10.1063/1.3633217]“
“Background: Dry skin causes pruritus and discomfort in patients with xerosis and atopic dermatitis. General treatment for skin dryness involves the topical application of an emollient. However, more effective, simpler therapies are desired. Collagen tripeptide (CTP) is a highly purified, non-antigenic, low-allergenic collagen fraction that is known to have various biological effects.

Objective: To clarify the therapeutic effects of CTP for dry skin using acetone-induced dry skin model mice.

Methods: ICR mice were treated with acetone followed by oral administration of CTP (80 or Epoxomicin 500 mg/kg/day) for 3 days. Hyaluronic acid production induced by CTP was assessed using human dermal fibroblasts in vitro and in an acetone-induced dry skin model mice in vivo. Transepidermal water loss (TEWL) and scratching behavior were evaluated. Furthermore, the effects of CTP on intraepidermal nerve fibers and expression of semaphorin 3A (Sema3A) and nerve growth

factor (NGF) were examined by immunohistochemistry and quantitative RT-PCR.

Results: CTP enhanced hyaluronic acid production in human dermal fibroblasts in vitro and in murine skin in vivo. Oral administration of CTP in acetone-induced dry skin model mice significantly decreased TEWL and suppressed scratching behavior. Intraepidermal nerve growth was dramatically inhibited in CTP-treated mice. Quantitative PCR analysis and immunohistochemical study revealed that CTP abolished the increased NGF and decreased Sema3A levels induced by acetone treatment.

Conclusion: Oral administration of CTP improves dry skin and normalizes axon-guidance factors in the epidermis in addition to reducing pruritus. CUP may be used in a new therapeutic strategy against dry skin and pruritus. (C) 2012 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.”
“Purpose: The aim of this study was to determine the rate of postoperative infection and the efficacy of removing teeth in the line of mandibular angle fractures treated with 2.0-mm 8-hole titanium Curved strut plates.

METHODS: This is a retrospective cohort study of all patients wit

METHODS: This is a retrospective cohort study of all patients with singleton gestations who presented to our institution for second-trimester ultrasonography between 1990 and 2008. Study groups were defined by the presence or absence of echogenic bowel. Primary outcomes were IUGR, defined as birth weight less than the 10th percentile for gestational age and intrauterine fetal demise at 20 weeks or more of gestation. Univariable and multivariable logistic regression analyses were used to estimate the risk of intrauterine fetal demise and IUGR in Vadimezan datasheet fetuses with echogenic bowel. Analyses

were repeated after excluding cases of aneuploidy, cytomegalovirus (CMV) infection, other major congenital anomalies,

and abnormal second-trimester serum screening results.

RESULTS: Of 64,048 patients, the incidence of echogenic bowel was 0.4%. Of these, echogenic bowel was an isolated finding in 188 (72.3%) cases. There Verubecestat were 579 (0.9%) cases of intrauterine fetal demise and 8,173 (12.8%) cases of IUGR in the entire cohort. After excluding cases of aneuploidy and CMV infection, the incidence of intrauterine fetal demise was 7.3% in the echogenic bowel group compared with 0.9% in the nonechogenic bowel group, translating to an absolute risk increase of 6.4%. The incidence of IUGR in the echogenic bowel group was 19.5% compared with 12.9% in the nonechogenic bowel group (absolute risk increase, 6.6%). After controlling for potential confounders, echogenic

bowel was significantly associated with both intrauterine fetal demise (adjusted Sepantronium mw odds ratio [OR] 9.6, 95% confidence interval [CI] 5.8-15.9) and IUGR (adjusted OR 2.1, 95% CI 1.5-2.9). This risk association remained significant even when evaluating echogenic bowel as an isolated sonographic finding.

CONCLUSION: The presence of echogenic bowel on ultrasonography is independently associated with an increased risk for both IUGR and intrauterine fetal demise. Serial growth assessment and antenatal testing may be warranted in these patients. (Obstet Gynecol 2011;117:1341-8) DOI: 10.1097/AOG.0b013e31821aa739″
“Research progress has provided detailed understanding of the molecular pathogenesis of Alzheimer disease (AD). This knowledge has been translated into new drug candidates with putative disease-modifying effects, which are now being tested in clinical trials. The promise of effective therapy has created a great need for biomarkers able to detect AD in the predementia phase, because drugs will probably be effective only if neurodegeneration is not too advanced. In this chapter, cerebrospinal fluid (CSF) and plasma biomarkers are reviewed.

Cognitive and emotional problems should be carefully monitored, p

Cognitive and emotional problems should be carefully monitored, providing prompt diagnosis ARS-1620 and treatment as appropriate.”
“An approximate continuum theory is developed to effectively handle the problem of interaction between dislocations and inhomogeneity of any shape and properties. The inhomogeneity is, based on the Eshelby equivalent inclusion theory, equivalent to a homogenous one with a transformation strain. The interaction

force between dislocation and the inhomogeneity can then be evaluated from the work done by the dislocation stress field during the transformation. The proposed continuum theory is applicable to a variety of inhomogeneities, such as pore, gas bubble, shear band and plastically deformed zone. It can be reduced to the classical continuum theory for some special cases. (C) 2011 American Institute

of Physics. [doi:10.1063/1.3592342]“
“The sea cucumber (Apostichopus japonicus) is an important item in Asian cuisine. It is currently produced through aquaculture, especially in China, after being overexploited in the wild in the 1990s. We isolated 70 novel polymorphic microsatellite loci using an enrichment-colony hybridization protocol. All loci were characterized in 48 individuals from a natural population in Rongcheng (Shandong, China) using genomic DNA isolated from muscle tissue. The number of alleles ranged from 2 to 17 (mean 7.0), and the observed and expected heterozygosities varied from 0.0010 to 1.0000 and from 0.2125 to 0.9477, respectively. Thirty-one of the 70 loci exhibited departure from Hardy-Weinberg equilibrium. These microsatellite markers should be useful resources for population genetic studies and for molecular marker-assisted breeding of A. japonicus.”
“Magnetic resonance imaging (MRI) techniques have contributed to ameliorate the understanding of the mechanisms responsible for the accumulation of cognitive impairment in patients with multiple sclerosis. Earlier

studies demonstrated a relationship of the location of T2-visible lesions in critical brain regions and atrophy of several brain compartments with the severity of cognitive impairment in these patients. More recently, the development of new postprocessing VE-821 sds approaches and the application of quantitative MR techniques for the assessment of structural disease-related damage in the brain normal-appearing white matter and gray matter resulted in a better understanding of the factors associated with the onset and development of deficits of several cognitive domains. In addition, the use of functional MRI has disclosed that brain cortical reorganization may play a role in limiting the neuropsychological consequences of structural damage in the different stages of the disease.

Here we first overview the state of the art in the literature on

Here we first overview the state of the art in the literature on the cardioprotective selleck chemicals llc effects of H(2)S in various models of cardiac injury. Subsequently, we present original data showing the beneficial effects of parenteral administration of a donor of H(2)S on myocardial and endothelial function during reperfusion in a canine experimental model of cardiopulmonary bypass. Overview of the literature demonstrates that various formulations of H(2)S exert cardioprotective effects in cultured cells, isolated hearts and various rodent and large animal models of regional or global myocardial

ischemia and heart failure. In addition, the production of H(2)S plays a role in myocardial pre- and post-conditioning responses. The pathways implicated in the cardioprotective action of H(2)S are multiple and involve K(ATP) channels, regulation of mitochondrial respiration, and regulation of cytoprotective genes such as Nrf-2. In the experimental part of the current article, we demonstrate the cardioprotective effects of H(2)S in a canine model of cardiopulmonary bypass surgery. Anesthetized dogs were subjected hypothermic cardiopulmonary bypass with 60 min of hypothermic cardiac arrest in the presence of either

saline (control, n = 8), or H(2)S infusion (1 mg/kg/h for 2 h). Left ventricular hemodynamic variables (via combined pressure volume-conductance catheter) as well as coronary blood flow, endothelium-dependent vasodilatation to acetylcholine and endothelium-independent check details vasodilatation to sodium nitroprusside were measured at baseline and after 60 min of reperfusion. Ex vivo vascular function and high-energy phosphate contents were also measured. H(2)S led to a significantly better recovery of preload recruitable stroke work (p < 0.05) after 60 min of reperfusion. Coronary blood

flow was also significantly higher in the H(2)S group (p < 0.05). While the vasodilatory response to sodium nitroprusside was similar in both groups, acetylcholine resulted in a significantly higher increase in coronary blood flow in the H(2)S-treated group (p < 0.05) both in vivo and ex vivo. Furthermore, high-energy phosphate contents were better preserved in the H(2)S group. Additionally, the cytoprotective effects of H(2)S were confirmed also using in vitro cell culture experiments in H9c2 cardiac ML323 mouse myocytes exposed to hypoxia and reoxygenation or to the cytotoxic oxidant hydrogen peroxide. Thus, therapeutic administration of H(2)S exerts cardioprotective effects in a variety of experimental models, including a significant improvement of the recovery of myocardial and endothelial function in a canine model of cardiopulmonary bypass with hypothermic cardiac arrest. (C) 2010 Elsevier Inc. All rights reserved.”
“The main work of this paper is to propose a new theory and method, which is based on the idea of the pseudo-amino acid composition, for phylogenetic analysis of DNA primary sequences.