(C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012″
“Infectious disease treatments, both pharmaceutical and vaccine, face three universal challenges: the difficulty of targeting treatments to high-risk ‘superspreader’ populations who drive the great majority of disease spread, behavioral barriers in the host population (such as poor compliance click here and risk

disinhibition), and the evolution of pathogen resistance. Here, we describe a proposed intervention that would overcome these challenges by capitalizing upon Therapeutic Interfering Particles (TIPs) that are engineered to replicate conditionally in the presence of the pathogen and spread between individuals – analogous to ‘transmissible immunization’ that occurs with live-attenuated vaccines (but without the potential for reversion to virulence). Building on analyses of HIV field data from sub-Saharan Africa, we construct a multiscale model, beginning at the single-cell level, to predict the effect of TIPs on individual patient viral loads and ultimately population-level disease prevalence. Our results show that a TIP, engineered with properties based on a recent HIV gene-therapy trial, could stably lower HIV/AIDS prevalence by, similar to 30-fold THZ1 cost within 50 years and could complement current therapies. In contrast, optimistic antiretroviral therapy or vaccination

campaigns alone could only lower HIV/AIDS prevalence by, <2-fold over 50 years. The TIP’s efficacy arises from its exploitation of the same risk factors as the pathogen, allowing it to autonomously penetrate

superspreader populations, maintain efficacy despite behavioral disinhibition, and limit viral resistance. While demonstrated here for HIV, the TIP concept could apply broadly to many viral infectious diseases and would represent a new paradigm for disease control, away from pathogen eradication but toward robust disease suppression.”
“Charged-particle microbeams, developed to provide targeted irradiation of individual cells, and then of sub-cellular components, and then of 3-D tissues and now organisms, have been instrumental in challenging Autophagy Compound Library purchase and changing long accepted paradigms of radiation action. However the potential of these valuable tools can be enhanced by integrating additional components with the direct ability to measure biological responses in real time, or to manipulate the cell, tissue or organism of interest under conditions where information gained can be optimized. The RARAF microbeam has recently undergone an accelerator upgrade, and been modified to allow for multiple microbeam irradiation laboratories. Researchers with divergent interests have expressed desires for particular modalities to be made available and ongoing developments reflect these desires. The focus of this review is on the design, incorporation and use of. multiphoton and other imaging, micro-manipulation and single cell biosensor capabilities at RARAF.

Reporter analysis performed using the regulatory region of the Gst-p gene revealed that H2A.Z and PR-SET7 repressed Gst-p promoter activity. The enhancer element responsible

selleck kinase inhibitor for hepatocarcinogenic-specific gene expression was required for repression by H2A.Z, and the negative regulation by PR-SET7 mediated the regulatory element but not the enhancer. Furthermore, we examined the effects of overexpression of H2A.Z and PR-SET7 on the colony formation activity of mouse NIH-3T3 cells grown on a soft agarose medium. Colony formation based on anchoring independent cell growth is a feature of malignant transformed cells. These factors did not exhibit colony formation activity but repression of the ras oncogene induced this activity. PR-SET7 suppressed RAS(val12)-mediated colony formation through methyltransferase activity. These results suggest that H2a.z and Pr-set7 that are induced during hepatocarcinogenesis may function as carcinogenesis suppressors.”
“We present the common milestones of the neurology and psychiatry in Brazil, but, find more previously, they were summarized in the European matrix. The main psychiatric and neurological historical interceptions may be recognized by the terms neurology, psychiatry, alienism, neurosis and insanity; its organogenesis or socio- and psychogenetic basis; and its proximity or distance from internal medicine.”
“Cerebral autosomal dominant arteriopathy

with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic disorder hallmarked by ischemic stroke and vascular dementia. Characteristic pathological changes in the vasculature include thickening of small arteries and accumulation of heterogeneous material within the vessel wall. We tested whether endothelial von Willebrand factor (vWF) accumulates in CADASIL vessels S63845 and whether exposure of smooth muscle cells to vWF alters the expression of smooth muscle gene expression. Brain sections obtained at autopsy from six North American CADASIL patients were examined using immunohistochemistry for vWF and IgG. Rat

aortic smooth muscle cells (A7R5 cells) were tested for binding to infrared tag-labeled vWF. Finally, A7R5 cells were exposed to vWF, and expression of mature smooth muscle marker genes was analyzed by quantitative reverse transcriptase PCR. vWF is expressed in the penetrating arterial walls in all CADASIL samples. IgG, a marker of serum extravasation, was present only in a minority of arterial walls. vWF binds to smooth muscle cells in vitro, and low concentrations of vWF rapidly activate c-Fos, Egr-1, TSP1, and c-Myc while specifically inhibiting RNA encoding smooth muscle actin, calponin, and SM22. These data demonstrate that vWF, likely produced by the endothelium, permeates the vessel wall of CADASIL brains. Exposure of smooth muscle cells to vWF results in reduction of specific RNAs required for normal vascular homeostasis.

(C) 2011 Elsevier Ireland Ltd. All rights reserved.”
“Allometry has been extensively used in the modern day drug development scenario to predict the human relevant parameters LY2835219 order (clearance, Cl, and volume

of distribution at steady state, V(ss)) from animal data. The applicability of allometry in the prediction of human parameters for irinotecan (CAS 97682-44-5), an important topoisomerase I inhibitor, has been retrospectively investigated. Literature pharmacokinetic data has been gathered for both irinotecan and its main metabolite, SN-38 (CAS 86639-52-3), from several animal species. The corresponding human parameters were predicted using allometry (Cl and Vss for irinotecan; Cl/F for SN-38). Although irinotecan has a complex metabolism and disposition profile,

it appeared that simple allometry predicted satisfactorily the human values for Cl (1.7648W(0.669)) and Vss (3.1277W(0.9044)) for irinotecan. On the contrary, Cl/F for SN-38 was over predicted by simple allometry (53.389W(1.2273)); and the applicability of bile correction factor rendered Cl/F of SN-38 to be closer GSK2126458 clinical trial to the observed human value (8.964W(1.3108)). The investigation suggests that prospective allometric approaches may aid in the development of future compounds in this important pharmacological and chemical class of cytotoxics.”
“This review article covers the concepts and the theory behind using nanoparticles (NPs) in separation

science. Recent examples show the use of NPs in capillary electrophoresis and electrochromatography. Specific examples involve the use of NPs in liquid, gas and ion chromatography, along with recent applications showing the use of NPs in microchip electrophoresis. Future trends and conclusions are also covered. (C) 2013 Elsevier Ltd. All rights reserved.”
“Objective: To evaluate the incidence of perioperative bleeding among children with mild bleeding disorders who underwent adenotonsillar surgery in our hospital and were treated with our perioperative bleeding prophylaxis protocol.

Methods: Retrospective chart review was aimed at determining the perioperative bleeding rate in children with mild bleeding MAPK inhibitor disorders subjected to our prophylactic protocol while undergoing adenotonsillar procedures. Low von Willebrand factor (LVWF), unspecific platelet function disorders (UPFD) and mild factor VII deficiency were considered as mild bleeding disorders. The protocol utilizes intravenous desmopressin, tranexamic acid, NSAID avoidance, and overnight observation.

Results: Between 2004 and 2009, 44 children with mild bleeding disorders underwent adenotonsillar procedures in our hospital and were treated with the protocol. One patient (LVWF + UPFD) developed perioperative bleeding (2.3%).

Women undergoing infertility treatment with low SR-B1 expression in granulosa cells were noted to have plasma estradiol levels half the normal levels and a significantly lower number of retrieved oocytes. In vitro, deficiency of SR-B1 is associated with lower progesterone secretion in human granulosa cells. Certain SR-B1 polymorphisms have been associated with lower follicular progesterone levels and a significantly lower clinical pregnancy rate.

Summary

Deficiency of SR-B1, particularly due to single-nucleotide polymorphisms, could explain some features of female human infertility.”
“A

non-puerperal uterine inversion in advanced uterovaginal prolapse is a rare occurrence. Even more unusual is the presence of bladder calculi in these two conditions, which has not been documented before. We report AC220 a case of acute urinary retention secondary to severe uterovaginal

prolapse associated with uterine inversion and multiple bladder calculi.”
“Purpose: To employ response surface methodology (RSM) for statistical optimization of formulation factors in the preparation of celecoxib-loaded microspheres.

Methods: Celecoxib microspheres were prepared by solvent evaporation method. Biodegradable/biocompatible polymers, Eudragit L-100 and polyvinyl pyrrolidone, were used in the encapsulation procedure. A central composite design employing Stat-Ease design Expert (R), version 7.0.3 having a unit value of alpha was used according to reference protocols to assess the influence of two independent variables this website URMC-099 datasheet (i.e., the concentration of the two polymers used) on four dependent variables (i.e., recovery, encapsulation efficiency

and % drug released). The polymers used were Eudragit-L100 (X-1) and polyvinyl pyrrolidone (X-2). The microspheres were characterized for size, shape, recovery (%), entrapment efficiency and drug release.

Results: The recovered total weight of microspheres ranged between 49.4 +/- 3.1 and 91.1 +/- 4.8 %, and it decreased with increase in the concentration of PVP. Entrapment efficiency was in the range of 54.1 +/- 2.9 to 95.6 +/- 3.7 %, and was also dependent on polymer concentration. The release of celecoxib increased with decrease in Eudragit L-100 concentration and increase in PVP concentration. Higuchi model was the best-fit drug release from all the formulations. Korsemeyer-Peppas release exponent (n) indicates that drug release pattern was non-Fickian diffusion.

Conclusion: Using RSM, it is possible to optimize the drug release properties of celecoxib-loaded microspheres. A celecoxib-loaded microsphere formulation with optimum recovery, entrapment efficiency and release behavior was proposed.”
“The ethyl acetate phase of Limoniastrum guyonianum Boiss. was used to separate 10 fractions by centrifugal partition chromatography. Phenolic contents and biological capacities were evaluated in all fractions.

Comparison to the response of embedded gauges has suggested a possible slight Crenigacestat inhibitor decrease in the absolute magnitude of stress. However, changing the encapsulation has no detectable effect on the gradient behind the shock in such polymeric systems. (C) 2010 American Institute of Physics. [doi:10.1063/1.3460812]“
“Purpose: To determine whether E-cadherin loss causes nonlobular cancers (NLCs) detected at mammographic screening to have different mammographic appearances than do NLCs with normal E-cadherin

expression.

Materials and Methods: This study design had hospital ethics committee approval; informed consent was waived. Membranous expression of E-cadherin was assessed immunohistochemically in patients younger than 70 years from a consecutive series FaraA of 1944 operable invasive breast cancers. Of those, 276 NLC cases (age range, 45-70 years) were common to a prospectively collected database of breast cancer detected at screening. The mammographic features of 131 NLCs with reduced E-cadherin

expression were compared with those of 145 NLCs with normal E-cadherin expression.

Results: NLCs with E-cadherin loss were more likely to manifest as an ill-defined mass and less likely to manifest noncomedo microcalcifications at mammography than were NLCs with normal E-cadherin expression (47 [35.9%] of 131 vs 35 [24.1%] of 145, P = .03; and one [0.8%] of 131 versus 13 [9%] of 145, P = .001; respectively). NLCs with E-cadherin loss were significantly larger (>= 15 mm) than NLCs with normal E-cadherin expression (71 [54.2%] of 131 NLCs vs 57 [39.3%] of 145; P = .01). Both groups had a similar distribution of grade, tumor CT99021 type, nodal metastases, and vascular invasion.

Conclusion: Invasive NLCs with reduced E-cadherin expression detected at screening are more likely to appear as ill-defined masses and less likely to manifest noncomedo microcalcifications than are NLCs with normal E-cadherin expression. NLCs with reduced E-cadherin expression appear to have mammographic features that make them difficult to detect at small sizes. (C) RSNA, 2009″
“P>This study attempted to establish

whether a calcineurin inhibitor (CNI)-free immunosuppressant regimen based on sirolimus (SRL) is associated with a preservation of conduit arteries endothelial function in kidney recipients or not. Twenty-nine kidney recipients were randomized to receive since transplantation SRL (n = 15) or cyclosporin A (CsA, n = 14) associated with mycophenolate mofetil (MMF) and steroids (6 months) in a parallel prospective study. Systolic, diastolic blood pressures, glomerular filtration rate (GFR) and radial artery flow-mediated dilatation (FMD) induced by postischaemic hyperaemia were assessed in a blind manner at one (M1) and 7 months (M7) after transplantation. Endothelium-independent dilatation was assessed by glyceryl trinitrate spray. There was no difference between the groups for all vascular parameters at M1.

(C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 116:1823-1831,2010″
“The electronic structures of In(4)Sn(3)O(12), In(5)SnSbO(12) and the intermediate solid solution In(4+x)Sn(3-2x)Sb(x)O(12) have been studied by x-ray photoemission spectroscopy. The surfaces were found be consistently rich in indium and deficient in tin, with the extent of the deviation from bulk stoichiometry decreasing with increasing cosubstitution of In and Sb for Sn. We find VX-689 that the valence band structure of the In(4+x)Sn(3-2x)Sb(x)O(12) solid solution evolves with the degree of cosubstitution and shows well-defined

features that arise from the hybridization of O 2p states with In 5s, Sn 5s, and Sb 5s states. We determine the fundamental electronic gaps of In(4)Sn(3)O(12) and In(5)SnSbO(12) as 2.66 eV and 2.79 eV, respectively. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3399769]“
“BackgroundManagement

of earlobe keloids is challenging because they are often resistant to treatment. The literature reports different treatment modalities with variable responses. Surgical excision with core fillet flap in combination with adjuvant intralesional steroid injection has not been thoroughly explored for keloid treatment, in spite of its positive therapeutic and cosmetic outcome.

ObjectivesTo evaluate the clinical efficacy of keloidectomy with core fillet flap and adjuvant intralesional steroid Galardin injection in treating earlobe keloids.

Materials and methodsBetween 2004 and 2012, 21 earlobe keloids were treated using keloidectomy with core fillet flap and given intraoperative intralesional steroid injections. Follow-up was scheduled 2weeks after the procedure and then monthly to administer intralesional steroid injections and to assess response, postoperative complications, recurrence,

and objective and subjective satisfaction.

ResultsThe clinical outcome efficacy was 87.6%. Mean follow-up was 21.9months. Immediate recurrence this website was 9.5%, with few complications encountered. Subjectively, 82.3% of the patients were highly satisfied.

ConclusionKeloidectomy with core fillet flap and adjuvant intralesional steroid therapy is an effective modality for the clinical management of earlobe keloids. This approach should be considered for the treatment of this difficult condition.”
“Tumour necrosis factor inhibitor (TNFi) therapy, either intravenous (IV) or subcutaneous (SQ), demonstrates similar efficacy in ankylosing spondylitis (AS). The objective of this study was to examine factors influencing patient preference of TNFi. Fifty-nine (79.7%) participants were male with mean age 43.9 years and disease duration of 22.0 years. Fifty-nine patients (79.7%) agreed with the statement ‘My doctor gave me a choice and I made a decision based on my personal preference’. Patients commenced first on IV TNFi most commonly cited reduced frequency of injections (96.6%), administration by a trained professional (89.7%) and use of infusion time for leisure activities (86.2%).

5 mm and +/-1.0 mm, the accuracy was 39% and 90% (Dentaport ZX), 31% and 82% (Raypex 5), PND-1186 research buy and 37% and 73% (Elements Diagnostic Unit and Apex Locator), respectively, with statistically significant differences between Elements Diagnostic Unit and Apex Locator and the other EALs.

Conclusion. None of the EALs yielded an accuracy of 100%. Within the limitations of the present study. Elements Diagnostic Unit and Apex

Locator proved to be less reliable than Dentaport ZX and Raypex 5 in the determination of the real working length. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108: e147-e151)”
“Particulate polymer composites of lsophthalate based unsaturated polyester resin filled with different concentrations of lead monoxide were prepared and investigated for physical, thermal, mechanical,

and gamma radiation shielding characteristics. The results of thermomechanical studies have been discussed in this article. The composites P5091 research buy were investigated to understand the effect of filler on glass transition temperature (T(g)) and thermal expansion coefficients (alpha) at various temperatures under cyclic heating and cooling conditions. The results show that T(g) values of composites appear to decrease slightly with increasing filler content. The composites were observed to exhibit three phases of thermal expansion during first heating and cooling cycles where as they exhibit only two phases during second heating cycle. An anomalous expansion of the composites was observed

in the temperature range from 60 degrees C to 110 degrees C only during first heating and it disappears in subsequent heating cycles. Further, all the composites were observed to exhibit a dimensional contraction only during first heating and cooling cycles. The cyclic heating and cooling technique using thermo-mechanical analyzer was observed to be very efficient in determining actual values of T(g) and also in determining the post curing temperatures of the polymer and its composites. (C) 2010 Wiley Periodicals, Inc. J April Polym Sci 117: 3623-3629, 2010″
“High-grade or malignant gliomas are aggressive cancers. The World Health Organization (WHO) grading system recognizes Vorinostat chemical structure grade III and grade IV primary brain tumors of astrocytic, oligodendroglial, or mixed lineage. Identification of these tumors is prompted by symptoms such as insidious headaches, seizures, or focal weakness or numbness, with imaging findings of an enhancing mass lesion. Following surgery, radiation therapy has been known since the late 1970s to improve survival in malignant gliomas. More recently, the concurrent use of temozolomide (TMZ) and radiation therapy and the incorporation of bevacizumab have offered hope for patients with glioblastoma (WHO grade IV glioma). Although radiation is regularly used for up-front treatment of grade III gliomas, the role of chemotherapy is still being refined.

62A degrees. For the modified technique, mean laminar length was 22.07 +/- A 2.38 mm, and the screw angle was 67.40A degrees A A +/- A 3.39A degrees. 95.6 % (108/113) of the children could insert a screw into the lamina (laminar width a parts per thousand yen4.5 mm), 72.6 % (82/113) could accept bilateral translaminar screws (laminar width a parts per thousand yen4.5 mm and laminar height a parts per thousand yen9 mm).

Our investigation provides insight into the anatomy

of C2 lamina in six pediatric age groups. Compared to adults, GSK1210151A the benefits of C2 translaminar screws fixation are more obvious in the pediatric spine which has a large C2 lamina. Compared to Wright’s technique, the modified technique should insert a screw with bigger insert angle and shorter screw length.”
“This study describes a chemotaxis assay of ferret polymorphonuclear cells (PMNs). The optimal conditions for this chemotaxis assay were investigated for three chemoattractants: zymosan activated serum (ZAS), recombinant human interleukin-8 (rhIL-8) and N-formyl-Met-Leu- Phe (fMLF). In this study, ferret polymorphonuclear cells (PMNs) reacted to ZAS and rhIL-8,

but not fMLF. The optimal concentration of ZAS and rhIL-8 were 5% and 100 ng/ml, respectively. The optimal incubation time of each reagent was 60 min. Due to the lack of response shown from fMLF, the existence of formyl peptide receptors (FPR) on ferret PMNs was investigated by evaluating FPR binding using flow cytometry. The receptor was not detected, implying that ferret neutrophils may lack FPR. This study JIB-04 in vivo confirms the fundamental experimental conditions for ferret PMNs chemotaxis SIS 3 and elucidates new findings

concerning FPR in ferret neutrophils. (C) 2009 Elsevier Ltd. All rights reserved.”
“OBJECTIVE: To characterise the geographic and spatiotemporal distribution of confirmed tuberculosis (TB) cases in Beijing between 2005 and 2009.

DESIGN: The yearly notification rate maps were used to describe the distribution of confirmed adult TB patients. Spatial autocorrelation (Moran’s I) and hot-spot analysis were adopted to detect the clusters and hot spots of TB.

RESULTS: The TB incidence rate (cases per 100 000 population) in Beijing increased from 29.8 in 2005 to 35.0 in 2009. The incidence rate was significantly higher in the Urban Development New District and the Ecologic Reservation Development District (>30/100000) than in the other districts. There was a significant spatial autocorrelation throughout the city (u = 2.58, P = 0.01). Evident clusters were observed in the Capital Functional Core District and the Urban Function Extension District (G(i)* > 1).

CONCLUSION: Spatial autocorrelation and hot-spot analysis may serve as efficient tools to detect space-time clusters and geospatial hot spots of TB incidence. Between 2005 and 2009, TB incidence in Beijing showed population density and mobility-dependent and ecosocial status-dependent space-time clusters and geospatial hot spots.

The apoptosis index in chondrosarcoma was examined by means of the TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling) assay. Curves

for overall survival were drawn according to the Kaplan-Meier method, and differences were analyzed with the log-rank test. The association of pVHL expression with the clinicopathologic parameters, Bax expression, apoptosis index, and overall survival for patients with chondrosarcoma was also analyzed.

Results: https://www.selleckchem.com/products/btsa1.html Levels of VHL protein (p = 0.005) and mRNA (p = 0.008) were significantly reduced in chondrosarcoma tissues as compared with the paired adjacent normal tissues. Immunohistochemical analysis showed decreased pVHL in a significantly higher proportion of chondrosarcomas selleck chemicals llc (64.7%) than benign cartilage tumors (29.4%). pVHL expression was positively correlated with Bax expression and the a poptosis index in chondrosarcoma. Longitudinal studies of a cohort of patients with chondrosarcomas showed that decreased pVHL expression significantly correlated with increased tumor. grade (p = 0.026)

but was not independently predictive of overall survival.

Conclusions: Reduced pVHL expression was associated with decreased apoptosis and increasing chondrosarcoma grade, but the relationship between these findings and chondrosarcoma pathogenesis requires further study.”
“The temperature dependence of the surface plasmon resonance energy and width in 5 nm spherical gold nanoparticles embedded in a polymer polytetrafluoroethylene matrix has been studied using absorption spectroscopy. The jumplike features have been observed in these dependences indicating the melting of gold nanoparticles at temperatures considerably lower than the bulk melting

point. The interaction between gold nanoparticles sufficiently affects the melting of nanoparticles. The increase Selleckchem JPH203 in the filling factor of the particles leads to a decrease in the melting temperature of gold nanoparticles. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3125274]“
“Presently, natural products, such as Piper umbellata L. (Piperaceae), have been evaluated as sources of antimicrobial agents with efficacies against microorganisms. The in vitro antimicrobial activity was performed by broth micro-dilution susceptibility assay, according to the protocols of the National Committee for Clinical Laboratory Standards, and described the antibacterial and antifungal activities of crude ethanolic extract and fractions obtained by partitions sequentially among water-methanol, methylene chloride and ethyl acetate, as well as the major constituent, 4-nerolidylcatechol from the aerial parts of P. umbellata L. Amphotericin B and ciprofloxacin were used as controls. Among the microorganism cultures, hydromethanol fraction demonstrated the pre-eminent antifungal activity.

Other statistical approaches developed in the field of spatial epidemiology are an alternative

to control for poorly-measured spatially-varying confounders. (C) 2013 Elsevier Ltd. All rights reserved.”
“Background: Implant-related impingement has been reported following metal-on-metal hip resurfacing, and reactive osseous patterns associated with implant-bone impingement have been identified. The check details purpose of this study was to determine the prevalence and clinical implications of radiographic signs of femoral neck-acetabular cup impingement following metal-on-metal hip resurfacing.

Methods: Serial anteroposterior and lateral radiographs made five to 12.9 years postoperatively were available for ninety-one of the first 100 metal-on-metal hip resurfacing procedures (in eighty-nine patients) performed by the senior author. These radiographs were reviewed by a single 5-Fluoracil mw independent observer, who was

blinded to the clinical results. Radiographic signs of impingement were assessed and were correlated with clinical outcomes.

Results: Twenty hips (in eighteen patients) had at least one of two reactive osseous signs: a solitary exostosis (six hips, 7%) and an erosive “”divot-type”" deformity (twenty hips, 22%). Each radiographic sign occurred predominantly at the superior aspect of the femoral neck just distal to the femoral component. None of the patients with such an impingement sign reported any symptoms or discomfort during examination of the

range of hip motion. These patients had a greater mean postoperative University of California Los Angeles activity score and a greater mean range of hip motion than the patients without an impingement sign. Based on the numbers available, there was no association between component size, abduction angle and anteversion angle of the socket, femoral stem-femoral shaft angle, or femoral component-femoral neck ratio and the occurrence of repetitive impingement signs on radiographs.

Conclusions: The reactive osseous features identified in this study should facilitate Selleckchem BMS-777607 the radiographic assessment of impingement in other patients following hip resurfacing arthroplasty. Longer-term follow-up is needed to determine whether radiographic signs of impingement are of prognostic consequence.”
“Background: Studies on the mechanisms of the association between illicit drug use and HIV/STI provide important insight into why there are disproportionate rates of HIV/STI among heterosexual African American men; far less work has been conducted to examine the associations between binge alcohol use and HIV/STI risks in this Population.

Objective: To assess whether binge alcohol use is associated with risky sexual behaviors and recent HIV/STI diagnosis among heterosexual African American men reporting multiple sex partners in the past year.